Well, Hitch-hikers was a comedy, too, and one that laughed at the human race rather than the genre. Perhaps leave it in, and add a second title for balance? Something like Red Dwarf? (though that mostly pokes fun at the Scouser destabilizing the space/time continuum in 36 parallel universes just because he fancies a curry and chips).

I don't think you need to worry too much about the difference between your story and satire. If an agent thinks it will generate enough interest to spark a debate about whether your metaphors are aimed at US foreign policy, you're on to a winner

Your key objective is to crack a smile across an agent's face. Do that and you're off first base (or whatever the correct idiom is).

Hoping this isn't too lazy or cheeky to say here... I would lose miscreants - I think the misfits carry it by themselves. I would delete all between charged and demons, and add who before encounter. (I think the who needs adding anyway, or the sentence is grammatically wobbly.)

I think, if the protagonist is named ironically, and he blunders his way through the story and somehow saves the Universe, that's funny. In the 2nd paragraph, I would select a single, vital plot element that gets the most humour across, rather than try to make sure I captured the whole plot in a nutshell.

I would try to show the agent that my protagonist is hilarious, as well as cute, charming, or otherwise sympathetic. If (as an agent) I can imagine a younger Tom Hanks or Robin Williams being utterly sincere and madly in love, and foiling the aliens who think they're three steps ahead of him, I can see it working.